Abstract

SAN MIGUEL FRAILE, P. et al. Expresion of E-cadherin and catenins in urothelial carcinomas. Actas Urol Esp [online]. 2007, vol.31, n.4, pp.355-360. ISSN 0210-4806.

Objetive: We examined the presence of E-cadherin and a, b and g catenins detected by immunohistochemistry and correlated with the classic variables: grade, stage and recurrence. Material and method: The authors evaluated 37 transitional cell carcinomas. Biopsy specimens included no recurrent transitional cell carcinoma (n=19) and recurrent transitional cell carcinoma (n=18). Association of E-cadherin and a, b and g catenins immunoreactivity with tumor grade, clinical stage and tumor recurrence was examined. Results: E-cadherin and g catenin expression were related to the clinical stage of the disease, a and b catenins were not correlated with grade, stage and recurrence of disease. Conclusions: Decreased E cadherin and g catenin expression were associated with advanced stage of the disease.

Keywords : Urothelial carcinoma; Bladder; E-cadherin; Catenin.

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