Abstract

ROMERO SELAS, E. et al. Insignificant prostate cancer: Analysis our series. Actas Urol Esp [online]. 2008, vol.32, n.5, pp.475-485. ISSN 0210-4806.

The objective of this study is to analyse the specimen of radical prostatectomy of patients who had, prior to the surgery insignificant prostate cancer biopsies. The end point is demonstrate the possibility of an active surveillance as a therapeutic option for prostate cancer in selected is the possibility of an active surveillance as therapeutic for the prostate cancer, in selected individuals if we are able to find diagnostic algorisms to predict the real insignificant tumours. The selected group of patients for the study has a PSA less or equal 10, one positive core of prostatic transrectal ultrasound biopsy with a Gleason score less than 7. This group of patients is considerate as having a potential insignificant tumour. We will consider prostatectomy’s specimens and the Gleason sore is less than 7 and the tumoral volume is les or equal to 5%. Of 394 patients with prostate cancer and homogeneous criterias for our study, we have selected 53 patients according to the criteria of insignificant tumour in the biopsy. Our results showed that only 22 of 53 (41.5%) patients were identified as having an insignificant prostate cancer in the RP specimens. Moreover 92.2 % of this tumours were organ- confined. In conclusion we are able to say that tumours of low- risk and low tumoral volume in the biopsy, do not correlate always to insignificant tumours in PR specimens, but we have observed that the majority are organ- confined tumours. Finally, the diagnostic’s algorisms dies not to predict tumours that may safely treated with active monitoring.

Keywords : Insignificant prostate cancer; Active surveillance; Prostate biopsy; Radical prostatectomy; PSA; Gleason score.

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