Abstract

LLARENA IBARGUREN, Roberto. Treatment of metastatic renal cancer: current validity of immunotherapy. Actas Urol Esp [online]. 2009, vol.33, n.5, pp.584-592. ISSN 0210-4806.

Objective:To assess the significance and effects of conventional immunotherapy for management of disseminated renal cancer. Materials and methods: Historical data from studies conducted with cytokines, interferon, and interleukin are reviewed, their combinations are evaluated, and the different relevant studies available are compared. Discussion: While diverse, results are poor in terms of objective response and its duration. Historical series using interleukin-2 achieved, despite severe side effects, disease remissions, some of them complete. Conclusions: Currently, after the advent of new drugs, use of conventional immunotherapy may be indicated for specific patients with a good general condition undergoing previous nephrectomy for a clear cell carcinoma at least 12 months before occurrence of metastasis in a single organ, preferably the lung, and with normal levels of hemoglobin, calcium, and lactate dehydrogenase, looking for that small percentage of stable and sustained responses.

Keywords : Immunotherapy; Cytokines; Interferon; Interleukin.

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