SciELO - Scientific Electronic Library Online

vol.36 issue6Circadian rhythm and time variations in out-hospital sudden cardiac arrestIs the critical patient competent for decision taking?: Psychological and psychopathological reasons of cognitive impairment author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Medicina Intensiva

Print version ISSN 0210-5691


AGUDELO, S.C. et al. Continuous propofol perfusion in critically ill children. Med. Intensiva [online]. 2012, vol.36, n.6, pp.410-415. ISSN 0210-5691.

Objective To describe sedation with continuous perfusion of propofol in critically ill children. Design A retrospective, descriptive observational study was carried out. Setting A pediatric intensive care unit. Patients Pediatric patients requiring sedoanalgesia between October 1, 2009 and September 30, 2010. Interventions None. Data collected Demographic, clinical and laboratory test variables, diagnosis, treatment, complications and evolution in each patient. In addition, the potential adverse effects associated with propofol administration were analyzed. Results: Midazolam, fentanyl and propofol were the most commonly used sedative and analgesic drugs. Seventy-one out of 222 patients (32%) received propofol in continuous infusion. The average dose was 2.1mg/kg/h (SD 1.3, range: 0.5 to 6), and the average duration of treatment was of 6.7 days (SD 8.5 range 0.5-40). Fifty-two percent were males, and the mean patient age was 45.8 months (median: 24; interquartile range: 7-65). No patient developed propofol infusion syndrome or other serious drug-related adverse effects. Patients treated with propofol showed more abnormal laboratory test findings, although no relationship to drug administration could be demonstrated. There were no significant differences in lactate level or in the incidence of infection in either group. Conclusions: Propofol at a dose of 1 to 4mg/kg/h is a safe alternative for sustained sedation in critically ill children. However, further studies are needed to assess its effects and safety profile.

Keywords : Propofol; Sedation; Propofol infusion syndrome; Pediatric intensive care.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License