Resumo

LEON CABALLERO, Jordi et al. Leucopenia and neutropenia rapidly evolving induced by olanzapine. Rev. Asoc. Esp. Neuropsiq. [online]. 2013, vol.33, n.119, pp.603-606. ISSN 2340-2733.  https://dx.doi.org/10.4321/S0211-57352013000300010.

Some antipsychotics drugs are associated with blood dyscrasias. The psychotropic medication most frequently associated with agranulocytosis is clozapine (0,5-2% of patients). Olanzapine is a second-generation antipsychotic with a chemical structure similar to clozapine, with a risk of neutropenic reactions of 1/10.000 treated patients. We report the case of a 32-year-old man without medical or psychiatric records, who was admitted due to a first psychotic episode. In a blood test previous to hospitalization, complete blood cell count was normal (white blood cell count 8,92x10³/ul, neutrophilic count 6,99x10³/ul). Three days after initiation of olanzapine 20mg/day, WBC count had fallen to 2,46x10³/ul (neutrophilic count 0,64x10³/ul). After replacing olanzapine, initially for risperidone and later for intramuscular zuclopentixol, WBC count gradually increased. On the twelfth day of olanzapine withdrawal, complete blood cell count had normalized (WBC count 5,73x10³/ul).

Palavras-chave : Olanzapine; leucopenia; neutropenia; agranulocytosis.

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