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Revista de la Asociación Española de Neuropsiquiatría

On-line version ISSN 2340-2733Print version ISSN 0211-5735


GONZALEZ MORENO, Antonio; GUTIERREZ CASTILLO, Daniel  and  PENUELAS CALVO, Inmaculada. Giant cavum septum pellucidum and cognitive impairment in schizophrenia: analysis of a clinical case. Rev. Asoc. Esp. Neuropsiq. [online]. 2015, vol.35, n.128, pp.831-835. ISSN 2340-2733.

Cavum septum pellucidum (CSP) is a morphological alteration of the septum pellucidum that should disappear at 3-6 months of age. CSPs that persist for longer, and non-communicating CSP, are classified as a neurodevelopmental disorders and have been associated with schizophrenia and other psychotic disorders, especially in cases with large CSPs. Prevalence rates vary according to the measurement method, and the figures range from 0,1% to 85% in the general population and from 15% to 44,8% in schizophrenia. A series of clinical features such as cognitive disorders, more negative symptoms and verbal learning and sentence comprehension disorders has been found in patients with psychotic disorders and large CSP. We present the clinical case of a 19-year old patient diagnosed with hebephrenic schizophrenia in which a CT scan revealed a giant CSP (2,6 cm) and who presented significant negative symptoms, cognitive deterioration, verbal learning and sentence comprehension disorders and important behavioural disorders.

Keywords : Cavum septum pellucidum; schizophrenia; cognitive impairment; neurodevelopment.

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