Abstract

GOMEZ MARCOS, M.A. et al. Differences in the CKD-EPI equation with MDRD for the estimation the glomerular filtration in hypertensive patients. Nefrología (Madr.) [online]. 2010, vol.30, n.4, pp.458-462. ISSN 1989-2284.

Objective: To analyze the agreement in glomerular filtration rate (GFR) estimated with CKD-EPI and MDRD-IDMS equations in a cohort of hypertensive patients. Methods: We included consecutively 478 hypertensive patients, 57.58 (SD: 12.34) aged, 68.3% males. The estimation of GFR was performed with MDRD-IDMS and CKD-EPI equations and we analyzed the agreement between them. Results: The estimation of GFR with CKD-EPI was 4.37 (95%:3.73-4.19) mL/min/1,73 m² higher than MDRD-IDMS, overall and by gender (males 3.99; females 5.04). In patients under 65 years the difference was greater, 6.55 (95%:5.95-7.15) mL/min/1.73 m² in both men 6.07 and women 6.48. However, we found no significant difference. Intraclass correlation coefficient was 0.904 (95%CI:0.886-0.919), 0.897 men and 0.917 women and Kappa index 0.848 (95% CI :0.795-0.889), 0.845 men and 0.852 women. Conclusion: CKD-EPI equation estimated a higher FG in hypertensive patients under 65 years and reclassified in stage 1 patients classified in stage 2 by MDRD-IDMS.

Keywords : Creatinine; Blood pressure; Glomerular filtration rate; Kidney diseases; diagnosis; Kidney diseases; epidemiology; Calibration.

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