Abstract

TOLEDO ROJAS, R. et al. Sjögren's syndrome and acute renal failure following oral surgery. Nefrología (Madr.) [online]. 2010, vol.30, n.4, pp.467-472. ISSN 1989-2284.

Primary Sjögren's syndrome is a multisystemic inflammatory disorder that mainly affects the exocrine glands and usually presents as dryness of the mouth and eyes. The wide clinical spectrum of the disease also includes general symptoms, extraglandular manifestations and lymphoma. The renal involvement is frequent. Interstitial nephritis is the most common renal manifestation, but glomerular involvement and acute renal failure may rarely occur. We describe a case of a female patient with primary Sjögren's syndrome complicated by severe acute renal failure due to cryoglobulinemic glomerulonephritis. Treatment with steroids, cyclophosphamide, plasma exchange and rituximab successfully led to recovery from acute renal failure.

Keywords : Cryoglobulinaemia; Sjögren´s syndrome; Rituximab; Acute renal failure.

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