Abstract

RAMIREZ, A. E.; FERNANDEZ, C.; NARVAEZ, D.  and  TENEUD, L.. Expression of epidermal growth factor receptor in renal biosy from patients with adolescent nephronophthisis. Nefrología (Madr.) [online]. 2010, vol.30, n.5, pp.518-521. ISSN 1989-2284.

Introduction: In Venezuela has been described a new form of nephronophthisis, called adolescent nephronophthisis, with clinical and histological findings very similar to others varieties described. However, pathogenesis in not well known. The aim of this study was to determine the expression of human epidermal growth factor receptor (EGFR) in tubular epithelial cells of patients with adolescent nephronophthisis. Methods: Renal biopsies of 8 patients with adolescent nephronophthisis were studied by immunohistochemistry to determine renal expression of EGFR. Results: In all patients, there was no expression of epidermal growth factor receptor. Conclusion: These findings indicate a deficiency of growth factor receptor in undifferentiated epithelial cells, which could be one factor in the development of cysts in nephronophthisis.

Keywords : Immunohistochemistry; Renal failure; Tubular basement membrane.

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