Resumo

BARDALLO CRUZADO, Leonor et al. Serum cystatin C levels in preterm newborns in our setting: correlation with serum creatinine and preterm pathologies. Nefrología (Madr.) [online]. 2015, vol.35, n.3, pp.296-303. ISSN 1989-2284.  https://dx.doi.org/10.1016/j.nefro.2015.05.004.

Background: Cystatin C (CysC) is a renal function marker that is not as influenced as creatinine (Cr) by endogenous or exogenous agents, so it is therefore proposed as a marker in preterm infants. Objectives: To determine serum CysC values in preterm infants during the first week of life, compared to Cr. To analyze alterations caused by prematurity diseases. Method: The design involved a longitudinal, observational study of prospective cohorts. Groups were based on gestational age (GA): Group A (24-27 weeks), Group B (28-33 weeks), Group C (34-36 weeks). Blood samples were collected at birth, within 48-72 hours and after 7 days of life. Statistics: SPSS v.20 software was used. The statistical methods applied included chi-squared test and ANOVA. Results: A total of 109 preterm infants were included in the study. CysC levels were: 1.54 mg/L (±0.28) at birth; 1.38 mg/L (±0.36) within 48-72 hours of life; 1.50 mg/L (± 0.31) after 7 days (p < 0.05). Cr levels were: 0.64 mg/dL (±0.17) at birth; 0.64 mg/dL (± 0.28) within 48-72 hours; 0.56 mg/dL (± 0.19) after 7 days (P < .05). CysC values were lower in hypotensive patients and those with a respiratory disease (P < .05), and no alterations associated with other diseases were observed. There were no differences in Cr levels associated with any disease. Creatinine levels were higher in patients ≤ 1.500 g (P < .05). Conclusions: Serum CysC decreased within 48-72 hours of life, and this decline showed significance (P < .05). The levels increased after 7 days in all 3 GA groups, and there was no difference in CysC levels among the groups. More studies in preterm infants with hypotension and respiratory disease are required. CysC is a better glomerular filtration (GF) marker in ≤ 1.500 g preterm infants.

Palavras-chave : Cystatin C; Creatinine; Premature infant.

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