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Nefrología (Madrid)

On-line version ISSN 1989-2284Print version ISSN 0211-6995

Abstract

ROVIRA, Jordi; DIEKMANN, Fritz; CAMPISTOL, Josep M.  and  RAMIREZ-BAJO, María José. Therapeutic application of extracellular vesicles in acute and chronic renal injury. Nefrología (Madr.) [online]. 2017, vol.37, n.2, pp.126-137. ISSN 1989-2284.  http://dx.doi.org/10.1016/j.nefro.2016.04.006.

A new cell-to-cell communication system was discovered in the 1990s, which involves the release of vesicles into the extracellular space. These vesicles shuttle bioactive particles, including proteins, mRNA, miRNA, metabolites, etc. This particular communication has been conserved throughout evolution, which explains why most cell types are capable of producing vesicles. Extracellular vesicles (EVs) are involved in the regulation of different physiological processes, as well as in the development and progression of several diseases. EVs have been widely studied over recent years, especially those produced by embryonic and adult stem cells, blood cells, immune system and nervous system cells, as well as tumour cells. EV analysis from bodily fluids has been used as a diagnostic tool for cancer and recently for different renal diseases. However, this review analyses the importance of EVs generated by stem cells, their function and possible clinical application in renal diseases and kidney transplantation.

Keywords : Extracellular vesicles; Acute and chronic renal injury; Regenerative therapy.

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