SciELO - Scientific Electronic Library Online

vol.28 issue4Alpha lipoic acid and its antioxidant against cancer and diseases of central sensitizationInter-methods agreement for the assessment of percentage of body fat between two laboratory methods in male adolescent cyclists author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Nutrición Hospitalaria

On-line version ISSN 1699-5198Print version ISSN 0212-1611


TAVARES DA SILVA, Sandra; ARAUJO DOS SANTOS, Carolina  and  BRESSAN, Josefina. Intestinal microbiota; relevance to obesity and modulation by prebiotics and probiotics. Nutr. Hosp. [online]. 2013, vol.28, n.4, pp.1039-1048. ISSN 1699-5198.

Introduction: The intestinal microbiota has several beneficial functions related to host health. Studies suggest that it may be related to the presence of metabolic diseases, including obesity. Objective: A bibliographic survey was carried out upon the relationship between the intestinal microbiota and obesity and the possible impacts of the use of prebiotics and probiotics, aiming to understand this complex and promising interaction. Methods: A search was conducted in the Lilacs, PubMed, SciElo and ScienceDirect databases, using the keywords "gut microbiota" and "obesity". Results and discussion: We identified 613 original studies. After careful selection, 61 original articles were included in this review. The others indicated that there are differences in the microbial composition between obese and non-obese patients and the possible mechanisms involved. Alteration is caused in the energy homeostasis, in the use of dietary intake and storage of lipids due to the composition of the intestinal microbiota. Among the studies that evaluated the microbiota modulation, seven used probiotics; 24 used prebiotics, and five studies were performed using food. After dietary manipulation, the growth of bifidobacteria was obtained in 10 studies, in association with weight reduction, adipogenic effects of diet, intestinal permeability and inflammatory markers. Conclusion: Knowledge on the impact of the microbiota on metabolic pathways allows to conceive new factors associated with obesity and modulation by prebiotics and probiotics. In this sense, the main effect observed was the increase in bifidobacteria, usually accompanied by weight loss and enhancement of parameters related to obesity.

Keywords : Intestinal microbiota; Obesity; Prebiotics; Probiotics.

        · abstract in Spanish     · text in English     · English ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License