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Nutrición Hospitalaria

versão On-line ISSN 1699-5198versão impressa ISSN 0212-1611


GONZALEZ JIMENEZ, David; BOUSONO GARCIA, Carlos; DIAZ MARTIN, Juan José  e  JIMENEZ TREVINO, Santiago. Fat-soluble vitamins supplementation in patients with cystic fibrosis: is enough Aquadek's®?. Nutr. Hosp. [online]. 2015, vol.31, n.4, pp.1625-1632. ISSN 1699-5198.

Introduction and objective: Evaluate the safety and efficacy of a novel polyvitaminic (Aquadek's®) in patients with Cystic Fibrosis (CF). Material and Methods: Prospective, longitudinal and non-randomized study. CF patients with pancreatic insufficiency and clinically stable were given Aquadek's® (two chewable tablets) daily for 12 months. Serum levels of retinol, beta-carotene, 25 OH vitamin D and α-tocopherol were evaluated twelve months before, at baseline and 12 months after. Statistical analysis: paired ttests. Results: 28 patients aged 6 to 39 years (median 18.5 years) were included. Aquadek's® supplementation led to an increase in vitamin A dose and a decrease in the number of tablets administered. At baseline, 89% had at least one vitamin deficiency (61% pro-Vitamin A and 54% vitamin D). After one year, serum beta-carotene levels were increases 160 (95% CI 98-222) mcg/l (p <0.001) and decreased the percentage of patients with pro-vitamin A deficiency 46% (95% CI 22-64) (p <0.001). The proportion of patients with vitamin D insuficiency increased 18% (95% CI 2-32) (p =0.025). In any case serum levels exceeded the upper limits used to assess the risk of toxicity. Conclusions: Two daily Aquadek's® chewable tablets are safe and effective for maintaining vitamin A and E status of CF patients older than 6 years, although it is insufficient to normalize serum 25OHvitaminD according to the current recommendations for this disease.

Palavras-chave : Fat-soluble vitamins; Crotenoids; Retinol; 25 OH vitamin D; Cystic fibrosis.

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