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Nutrición Hospitalaria

On-line version ISSN 1699-5198Print version ISSN 0212-1611


ROMERO-MORALEDA, Blanca  and  PRONAF STUDY GROUP et al. Lipid profile response to weight loss program in overweight and obese patient is related with gender and age. Nutr. Hosp. [online]. 2015, vol.31, n.6, pp.2455-2464. ISSN 1699-5198.

Introduction: the risk of developing cardiovascular disease (CVD) increases with age, however CVD is markedly higher in men than in no-menopausal women. There are few interventions where compare the different effects to lose weight on lipid profile between men and women. Objective: the aim of this study was to compare the response on the lipid profile by gender after a weight loss program, and determine whether there are differences by age group. Methods: one hundred eighty (96 women and 84 men) overweight and obese participants (BMI 25-34.9 kg/ m2) aged 18-50 years were randomised into treatment groups. The intervention period was 22 weeks (in all cases 3 times/wk of training for 22 weeks and 2 weeks for pre and post evaluation). All subjects followed a hypocaloric diet (25-30% less energy intake). Energy intake, body composition) and blood lipid profile were recorded at baseline and after of treatment. Results: the response of HDL varied between men and women (p = 0.001). While in women it decreased (HDL: -2.94%, p = 0.02), HDL was elevated in men (HDL: 5% p = 0.02). After intervention men achieved decrease significantly LDL values a 6.65% more than women (p = 0.01). For TG concentrations there were significant differences between men and women in baseline however, only men had a significant chance in post-training measured (p = 0.001). TC showed significant differences between men and women in baseline (p = 0.013). After intervention, men and women showed a significant decreased to TC (p = 0.01). Conclusion: men achieve a positive greater change on lipid profile than women. In addition, the favorable lipid profile response decreases with increasing age.

Keywords : Lipoprotein; Gender; Overweight; Obese; Weight loss treatment; Clinical trial.

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