Abstract

PEREZ CRUZ, Elizabeth; REYES MARIN, Arturo; ASBUN BOJALIL, Juan  and  ARTEAGA MORFIN, Jose Ignacio. Effectiveness of immunonutrition on inflammatory markers in patients with cancer: randomized clinical trial. Nutr. Hosp. [online]. 2015, vol.32, n.4, pp.1676-1682. ISSN 1699-5198.  https://dx.doi.org/10.3305/nh.2015.32.4.9507.

Background: malnutrition is a common complication in patients with cancer and is associated with immunosuppression and alterations with inflammatory response. Objective: the aim of our study was to evaluate the effect of enteral nutrition supplemented with two enteral formulas on inflammatory markers (CRP, IL-6 and FNTα) in cancer patients undergoing chemotherapy. Design and methods: randomized control trial, conducted at the Hospital Juarez of Mexico in patients with cancer undergoing chemotherapy with IRN < 97.5 and SGA B/C. Patients were randomly allocated to two groups: group I (immunomodulatory), group II (high ω3). The intervention began on the first day of chemotherapy until day 10 after. We evaluated nutritional status and an inflammatory marker on days 0, +5, +10 QT. Statistical analysis was performed with T Student, x² and analysis of variance for repeated measurements. P < 0.05 was considered statistically significant. Results: a total of 29 patients were analyzed, 27 (62.8%) females and 16 (37.2%) males. Mean age 43.91 + 11.3 years old. Malnutrition prevalence was 48.8% moderate and 51.2% severe. Prealbumin levels significantly increase in group II vs group I (p < 0.05). Both groups maintenance body weight, lean mass and fat mass. No decrease levels of CRP, IL-6 and FNTá. Conclusions: enteral supplementation during chemotherapy inhibits nutritional deterioration and maintenance body weight and lean mass. No decreased levels of inflammatory markers.

Keywords : Nutrition; Immunonutrition; Inflammation; Cancer.

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