Abstract

LUIS, D. A. de; IZAOLA, O.  and  ALLER, R.. Assessment of the genetic modification inducing diet through blood mononuclear cells. Nutr. Hosp. [online]. 2015, vol.32, n.6, pp.2478-2483. ISSN 1699-5198.  https://dx.doi.org/10.3305/nh.2015.32.6.10052.

The term nutrigenomics was created to describe how nutrition affects genes and the functions of the protein, at the transcriptional level, proteomic, and metabolic. Using changes in gene expression in blood mononuclear cells could be a model to assess the dietary intervention studies in order to understand the underlying mechanisms and impact of diet and nutrients in atherosclerosis, resistance insulin, obesity and diabetes mellitus. There are studies that have changed the dietary intake of cholesterol, polyunsaturated fat, monounsaturated, antioxidants and decreased caloric intake showing a variety of effects on the expression of mRNA in blood mononuclear cells related to inflammation, immunity, lipid metabolism genes, etc. These molecular findings entrench awareness of our body's response to diet and open up the possibility of rapid analysis of new diagnostic pathways in this area of knowledge and even new therapeutic tools.

Keywords : Gene expression; RNAm; Nutrigenomics; Blood mononuclear cells.

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