SciELO - Scientific Electronic Library Online

 
vol.35 número3Evaluación nutricional de pacientes geriátricos con enfermedad de Alzheimer en el Sur del Brasil: estudio de controles de casoLa adiposidad visceral aumenta el riesgo de cáncer de mama: un estudio de casos y controles índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Não possue artigos similaresSimilares em SciELO
  • Em processo de indexaçãoSimilares em Google

Compartilhar


Nutrición Hospitalaria

versão On-line ISSN 1699-5198versão impressa ISSN 0212-1611

Resumo

NONINO, Carla B. et al. Green tea supplementation promotes leukocyte telomere length elongation in obese women. Nutr. Hosp. [online]. 2018, vol.35, n.3, pp.570-575. ISSN 1699-5198.  https://dx.doi.org/10.20960/nh.1392.

Introduction:

inflammation and oxidative stress are factors that may play a substantial role in telomere attrition. In line of this, obesity is associated with telomere shortening. Green tea had anti-inflammatory and antioxidant effects and may alter telomere length (TL).

Objectives:

we evaluated the effect of decaffeinated green tea supplementation in obese women on TL.

Methods:

we conducted a cross-sectional interventional study with ten obese (body mass index [BMI] > 40 kg/m²) and eight normal weight (BMI > 18.5 and < 24.9 kg/m²) women (age between 27 and 48 years). The supplementation was carried out with capsules (each contained 450.7 mg of epigallocatechin-3-gallate) during eight weeks. Anthropometric and dietary intake assessment, and blood collection (for biochemical and TL analysis by quantitative PCR) were performed before and after supplementation. Normal weight patients were evaluated at a single moment.

Results:

we observed a significant increase on TL after supplementation (1.57 ± 1.1 to 3.2 ± 2.1 T/Sratio; p < 0.05). Moreover, we found shorter TL in obese patients (day 0) when compared to normal weight individuals (3.2 ± 1.9 T/Sratio; p < 0.05) and an inverse association between TL and BMI, even after age adjustment (beta = -0.527; r² = 0.286; IC = -0.129, -0.009).

Conclusion:

obesity is related to shorter telomeres. Green tea supplementation during eight weeks promotes telomere elongation in obese women.

Palavras-chave : Obesity; Epigallocatechin-3-gallate; Green tea; Telomere length; Supplementation.

        · resumo em Espanhol     · texto em Inglês     · Inglês ( pdf )