SciELO - Scientific Electronic Library Online

vol.36 issue3Evolution in anthropometric variables related to training and nutritional parameters in ultra-endurance mountain runnersCasein-derived peptides as an alternative ingredient for low-phenylalanine diets author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Nutrición Hospitalaria

On-line version ISSN 1699-5198Print version ISSN 0212-1611


PEREZ, Victoria et al. Efficacy of urine urea nitrogen measurement to assess the compliance with protein restricted diets. Nutr. Hosp. [online]. 2019, vol.36, n.3, pp.714-717.  Epub Feb 17, 2020. ISSN 1699-5198.


protein restriction is the mainstay of dietary management of chronic kidney disease.


to assess the usefulness of urine urea nitrogen measurement as a marker of protein restriction.


healthy young participants were randomly divided in two groups. During 14 days, one group received a diet containing 30 kcal/kg body weight and 1 g protein/kg body weight and the other group received a diet with the same amount of calories and 0.6 g/kg of proteins. At baseline, seven days and 14 days, 24 h dietary recalls were answered by the participants. They collected 24 hour urine and provided spot urine samples at baseline and at the end of the intervention, to measure creatinine and urea nitrogen.


forty-one participants aged 29 ± 5 years completed the follow-up. According to 24h dietary recalls, the group receiving 0.6 g/kg protein reduced significantly the protein intake during the intervention from 0.88 ± 0.06 to 0.59 ± 0.05 g/kg/day. A significant reduction in 24 h urea nitrogen excretion was also observed in this group. In the group receiving 1 g/kg of protein, no significant changes in 24 h urea nitrogen excretion were observed. Among all participants, the odds ratio of observing a reduction in protein intake in the dietary survey was 5.75 (95% confidence intervals 1.29-25.55, p = 0.02), when a reduction in 24 h urea nitrogen excretion corrected by creatinine was observed. No changes were observed in urea nitrogen excretion in spot urine samples.


repeated urea nitrogen excretion measured in 24 h urine samples can be a reliable indicator of dietary protein restriction.

Keywords : Protein restriction; Urine nitrogen; Kidney disease.

        · abstract in Spanish     · text in English     · English ( pdf )