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Nutrición Hospitalaria

versión On-line ISSN 1699-5198versión impresa ISSN 0212-1611


GUZMAN, Germán et al. Multidisciplinary methodology and ketogenic diet in real clinical practice: efficacy and rapidity in weight loss. Survival analysis PROMET Lipoinflammation Study. Nutr. Hosp. [online]. 2020, vol.37, n.3, pp.497-505.  Epub 16-Oct-2020. ISSN 1699-5198.


the aim of the current work was to evaluate the response time to a method of weight loss that includes dietary guidelines, physical exercise and emotional support. The response was defined as a loss of 10 % of the baseline weight.


data was obtained from the patients’ record recruited in Promet Lipoinflamación, an observational study of real world data in obese or overweight patients treated with a multidisciplinary method and based initially on a very-low-calorie ketogenic (VLCK) diet. Weight loss rate was evaluated through a survival analysis Kaplan-Meier and related factors through Cox regression).


6,369 subjects were included and 74.4 % managed to reach a weight loss of 10 % in a mean time of 57.64 days (IC 95 %: 56.95-58.33). The factors associated with a greater probability of reaching a loss of 10 % or more were male gender (RR: 1.37, p < 0.001), obesity types I, II and III vs. overweight (RR: 1.24, p < 0.001, 1.26, p < 0.001 and 1.22, p < 0.001, respectively) and young age vs. more than 55 years old (RR: 2.17, p < 0.001).


results obtained through real clinical practice show that the method produces fast and intense weight loss. Three out of four patients lost at least 10 % of body weight in an average of 58 days.

Palabras clave : Very-low-carbohydrate ketogenic diet; Weight loss; Response time; PnK® method.

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