SciELO - Scientific Electronic Library Online

vol.37 issue4Delphi method to reach consensus on education methods to promote healthy eating behaviors in adolescentsSarcopenia and inflammation in patients undergoing hemodialysis author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Nutrición Hospitalaria

On-line version ISSN 1699-5198Print version ISSN 0212-1611


AGUILAR-USCANGA, Blanca R et al. In vivo assessment of the protection conferred by β-glucans from Pleurotus ostreatus against the harmful effects of acrylamide intake (Part I). Nutr. Hosp. [online]. 2020, vol.37, n.4, pp.850-854.  Epub Dec 14, 2020. ISSN 1699-5198.


acrylamide is formed in food through Maillard’s reaction during thermal processing, and has been shown to be neurotoxic in humans, and a possible carcinogen. Studies have shown that β-glucans from Pleurotus ostreatus have diverse biological properties such as antioxidant and anticancer activities.


the aim of this work was to evaluate the protective effect of β-glucans from Pleurotus ostreatus against the harmful effects of acrylamide consumption in mice.


β-glucans were obtained by alkaline-acid hydrolysis of Pleurotus ostreatus, and the content was characterized by liquid chromatography. To evaluate the effect of β-glucans on the expression of glutathione, Balb/c mice were used, and 4 test groups were established. All groups were fed normally, and the groups treated with acrylamide were administered the compound intragastrically at a concentration of 50 μg/mL; β-glucans were administered at a concentration of 50 μg/mL.


mice exposed to acrylamide showed a marked variation in the activity of glutathione enzymes in the liver. Significant differences (p < 0.05) were only found in the expression of glutathione transferase, which was increased almost 3 times in the group treated with β-glucans as compared with the control group, and 1.5 times as compared with the group treated with acrylamide.


the results show that β-glucans could act by increasing the activity of enzymes involved in xenobiotic detoxification, thus protecting the biological system against the harmful effects caused by acrylamide intake.

Keywords : Protection; Acrylamide; β-glucans; Enzyme activity; Toxicity.

        · abstract in Spanish     · text in English     · English ( pdf )