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Nutrición Hospitalaria
On-line version ISSN 1699-5198Print version ISSN 0212-1611
Abstract
ALLER, Rocío et al. Association of the leptin receptor rs1805134 polymorphism with obesity parameters, dietary intakes, and metabolic syndrome in Caucasian obese subjects. Nutr. Hosp. [online]. 2023, vol.40, n.1, pp.35-40. Epub Apr 17, 2023. ISSN 1699-5198. https://dx.doi.org/10.20960/nh.04139.
Background:
some studies have evaluated the association of the rs1805134 genetic variant of the LEPR gene with obesity.
Aims:
the objective was to explore the association of the rs1805134 genetic variant of the LEPR gene with obesity measures and metabolic syndrome in obese Caucasian adults.
Methods:
we conducted a cross-sectional study in 212 obese subjects with body mass index (BMI) greater than 30 kg/m2. Measurements of adiposity parameters, blood pressure, fasting blood glucose, insulin concentration, insulin resistance (HOMA-IR), lipid profile, C-reactive protein, and prevalence of metabolic syndrome were determined.
Results:
the distribution of rs1805134 was 128 TT (60.4 %), 77 TC (36.3 %), and 7 CC (3.3 %). C-allele carriers showed higher levels of BMI, body weight, body fat mass, waist circumference, insulin, HOMA-IR, triglycerides, total energy intake, and carbohydrate intake than non-C-allele carriers. A logistic regression analysis reported a high percentage of elevated waist circumference (OR = 2.22, 95 % CI = 1.201-4.97; p = 0.02), hyperglycemia (OR = 1.54, 95 % CI = 1.01-5.44; p = 0.01), and metabolic syndrome percentage (OR = 1.41, 95 % CI = 1.04-5.39; p = 0.03) in C-allele carriers.
Conclusions:
subjects with the C-allele of the rs1805134 variant of the LEPR gene showed a worse metabolic pattern with a higher percentage of metabolic syndrome, central obesity and hyperglycaemia, probably related to higher energy intake.
Keywords : Energy intake; rs1805134; LEPR gene; Metabolic syndrome.