SciELO - Scientific Electronic Library Online

vol.40 issue2Influence of diet in COVID-19 infection and severity risk: a systematic review author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Nutrición Hospitalaria

On-line version ISSN 1699-5198Print version ISSN 0212-1611


MACHO-GONZALEZ, Adrián; MARTINEZ-SESMERO, José Manuel  and  SANCHEZ-MUNIZ, Francisco J. Autophagy, a relevant process for metabolic health and type-2 diabetes. Nutr. Hosp. [online]. 2023, vol.40, n.2, pp.457-464.  Epub June 05, 2023. ISSN 1699-5198.

Autophagy is a very active process that plays an important role in cell and organ differentiation and remodelling, being a crucial system to guarantee health. This physiological process is activated in starvation and inhibited in the presence of nutrients. This short review comments on the three types of autophagy: macroautophagy, microautophagy, and chaperone-mediated autophagy, as well as different aspects that control autophagy and its relationship with health and degenerative diseases. As autophagy is highly dependent on functional autophagy (ATG) proteins integrating the phagophore, the role of some key ATG genes and epigenes are briefly commented on. The manuscript deepens discussing some central aspects of type-2 diabetes mellitus (T2DM) and their relationship with the cell cleaning process and mitochondria homeostasis maintenance, as well as the mechanisms through which antidiabetic drugs affect autophagy. Well-designed studies are needed to elucidate whether autophagy plays a casual or causal role in T2DM.

Keywords : Autophagy; Types; ATG genes; Degenerative diseases; Type-2 diabetes; Antidiabetic drugs.

        · abstract in Spanish     · text in English     · English ( pdf )