Abstract

MORENO-PALOMARES, J.J. et al. Low-molecular-weight heparin versus  unfractionated heparin in the treatment of deep vein thrombosis. An. Med. Interna (Madrid) [online]. 2001, vol.18, n.7, pp.24-28. ISSN 0212-7199.

Background: Low-molecular-weight heparin (LMWH) are replacing unfractionated heparin (UH) in treatment of deep vein thrombosis (DVP), showing their security and effectiveness.  Methods: To demonstrate their security and effectiveness a randomized prospective study was realised. It compaired UH with LMWH in DP treatment, clinically diagnosed and confirmed with eco-Doppler. The study included 32 patients (21 males and 11 femeles); 15 received UH in continuos i.v. infussion and 17 sodic dalteparine, with dicumarinic afterwards in every case. The patients were followed for one year.  Results: There were no differences between the two groups of treatment in clinical/radiologycal effectiveness either in short term nor one year follow up. There were no significative differences in side effects.  Conclusion: LMWH are as effective and safe as UH for DVT treatment. They also have a more confortable dosage for the patient, avoiding the i.v. infusion and the coagulation test, which allows treatment at home.

Keywords : Low-molecular-weight heparin; Treatment; Thromboembolic disease.

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