Abstract

MARTINEZ VAZQUEZ, C. et al. Computed tomography appearance of Kikuchi-Fujimoto's disease: (histiocytic necrotizing lymphadenitis). An. Med. Interna (Madrid) [online]. 2002, vol.19, n.4, pp.31-37. ISSN 0212-7199.

Histiocytic necrotizing lymphadenitis, Kikuchi Fujimoto's disease (KFD) is characterised by fever and lymphadenopathy,usually large cervical, unilateral lymph nodes. Such clinical presentation demands a work-up to exclude serious medical conditions like malignancy and infections. Foci of necrosis with lymphocytic Histiocytic predominance in association with scarce polymorphonuclear cells on lymph node examination, confirm the diagnosis of KFD. Many different patterns of computed tomographyc (CT) appearance of KFD have been reported. We describe the CT scan finding in two patients with this disease.  All our cases showed, after two and three weeks of evolution respectively, enlarged lymph nodes with hypodense centres and peripheral ring enhancement. These radiological alterations correlated with the central lymph node necrosis found in the anatomopathologycal studies.  In conclusion, KFD should be considered in patients with fever, cervical lymph node enlargement and CT scan showing hypointense centres and peripheral ring enhancement. 

Keywords : Kikuchi Fujimoto's disease; Histiocytic necrotizing lymphadenitis; Computed tomography.

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