SciELO - Scientific Electronic Library Online

vol.20 número3Factores relacionados con el control glucémico de pacientes con diabetes tipo 2 índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados


Anales de Medicina Interna

versión impresa ISSN 0212-7199


MERA VARELA, A.; BLANCO RODRIGUEZ, J.  y  CAAMANO FREIRE, M.. Approximation to the cost of pharmacological treatment of rheumatoid arthritis in Spain. An. Med. Interna (Madrid) [online]. 2003, vol.20, n.3, pp.10-19. ISSN 0212-7199.

Objective: To study the direct cost derived of utilization of pharmaceutical compounds in the treatment of rheumatoid arthritis(RA).  Material and methods: A prospective study with 150 patients (125 women/25 men) suffered of RA was carry out in Galicia-Spain public hospital. The mean age was 60,2 years , with a mean lengthy of disease of 11,2 years (1-53); the 64,4% come from rural areas. A personal interview was made with a complete registry of all data: demographic, activity score (ESR, Swollen joints), radiological status, functional class (ACR), extrarticular manifestations and co-morbid diseases. Such data was accomplished with all the medications employees with a calculation of monthly or annual cost for the different therapeutic groups and a final total cost. The statistical study was made with Excel´s (Microsoft) and the Analysis Tool Pack.  Results: The 53% of patients was in functional class I and 52% in radiological stage I or II (Steinbrocker) whereas 16 patients was considered in remission. Non-steroideal ant-inflammatory drugs (NSAID) were used in the 82.7% of patients with a monthly cost of 12.71 € (1.10-80). Corticosteroids at low doses were used in 90.7% with a monthly cost of 5.17 € (1.24-33.7). The Disease Modifying Anti-rheumatic Drugs (DMARD) was used in 94% of cases, the most common methotrexate and association of two or more in 21%. The mean monthly cost for a single DMARD was 3,63 € and for two, 13.75 €. Gastroprotection and therapy for co-morbid diseases was employee in 80% and 95% of cases, with a monthly cost of 36,9€ and year cost of 568.6 €, respectively. The study included 23 patients under treatment with anti-TNF therapy with a monthly mean cost of 933.8 €. For pharmaceuticals exclusively for RA, annual cost was 342.8 € excluding anti-TNF therapy, but with wide variation (6.4-2.910 €). If we include all patients with anti-TNF therapy, gastro-protection and co-morbid situations in a calculation, the mean cost was 2,587 € year. The most important cost was found in patients with 50-70 years-old and existing a good correlation between the final burden and use of medications for co-morbid conditions, gastro-protection, use of anti-TNF, age, lengthy of disease between 5-10 years and number of swollen joints, but not radiological stage.  Conclusions: The economic burden for pharmaceuticals used in RA is very variable depending of some variables, including the proper disease and other related conditions. The most important cost occur in case of use of anti-TNF therapy. In the most frequent conditions, gastro-protection and therapy for co-morbid diseases lead the 62% of total annual burden, followed by the use of DMARD and in a minor load, the NSAIDs and corticosteroids.

Palabras clave : Rheumatoid; Arthritis; Economic; Cost; Pharmacological.

        · resumen en Español     · texto en Español     · Español ( pdf )


Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons