Abstract

CAMPOS FRANCO, J. et al. Late-onset Wilson’s disease. An. Med. Interna (Madrid) [online]. 2003, vol.20, n.8, pp.32-34. ISSN 0212-7199.

A 58-year old male with a past history of psychiatric disorders was studied for a persistent serum transaminase increase. Low serum ceruloplasmin level (lower than 3 mg/dL), increased urinary copper excretion, and increased liver tissue copper concentration (1050 mcg/g dry weight) confirmed the diagnosis of Wilson’s disease. Slit lamp examination did not show Kayser-Fleischer rings. D-penicilamin therapy was followed by serum transaminase normalization. Similar late-onset cases of Wilson’s disease are exceptional, but confirm the clinical heterogeneity of the disease.

Keywords : Wilson’s disease; Late-onset; Copper.

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