Abstract

SOLANO REMIREZ, M. et al. Lactic acidosis in diabetic patient treated with metformin. An. Med. Interna (Madrid) [online]. 2004, vol.21, n.6, pp.38-40. ISSN 0212-7199.

We present a case of metabolic acidosis ina man, recently diagnosed with type 2 Diabetes Mellitus under treatment with metformin. Metformin (along with Fenformin and Butformin) is an oral antihyperglycemic agent belonging to the biguanide group employed in the treatment of non insulin dependent diabetes (NIDDM). Its main use is in associattion with other oral agents in obese diabetic patients with difficult metabolic control. In some of these patients, clearly beneficial developed lactic acidosis, specially in those who have predisposing factors (respiratry failure, liver disease or cardiovascular disease) and/or those who require high dosis. For this reason we describe it´s pharmacokinetics, therapeutic indications and its correct use in this type of diabetic patient.

Keywords : Metformin; Biguanide; Lactic acidosis; Diabetes mellitus; Cardiorespiratory failure.

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