Abstract

BATUECAS MOHEDANO, M.; CARBALLO ALVAREZ, F.  and  GARCIA MENENDEZ, L.. Follow-up of serum monoclonal gammopathy at Guadalajara Health Area. An. Med. Interna (Madrid) [online]. 2006, vol.23, n.12, pp.569-572. ISSN 0212-7199.

Objective: To study the clinical course of patients with a serum monoclonal protein at Guadalajara Health Area. Material and methods: Prospective study of 186 patients with a newly diagnosed monoclonal component. They have been collected during the years 1999 and 2000. Results: The cumulative transformation probability at 43 months was 4.99% for those patients whose monoclonal gammopathy was overlooked, and 2% at 23 months for patients with monoclonal gammopathy of undetermined significance. The cumulative probability of survival for patients with multiple myeloma was 66.7% at 21 months. The conditional mortality rate (patients/months) at 4 years due to haematological disease was 4.48x10^-4 for overlooked patients, 0 for diagnosed of monoclonal gammopathy of undetermined significance and 1.388x10^-2 for multiple myeloma diagnosed. Discussion: A non malignant M component must be followed up due to it could increase patients' survival rate in relation with transformation in malignant disease.

Keywords : Monoclonal gammopathy; Plasma cells dyscrasias; Electrophoresis; Multiple myeloma; Waldenström macroglobulinemia.

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