Abstract

PENA PORTA, J. M.; VERA FLORISTAN, C. V. de  and  BUENO LOZANO, M.. Hidden renal failure and drug prescription in hospitalized patients. An. Med. Interna (Madrid) [online]. 2007, vol.24, n.5, pp.221-226. ISSN 0212-7199.

Objetive: Equations used to estimate glomerular filtarion rate (GFR) are useful to detect "hidden" renal failure (RF) ( coexistence of normal serum creatinine together with GFR < 60 ml/mto/1.73 m² ). The aim of this study was to anayze the prevalence of this phenomenon in hospitalized patients and how this affects drugs prescription. Patients and method: 567 patients admitted to the internal medicine section of Barbastro Hospital (Huesca, Spain) during a three months period (april-june 2006) were included. GFR was estimated applying abreviated MDRD equation. By means of logystic regresion analysis we analyzed the factors associated with the presence of "hidden" RF. We also recorded the potentialy dangerous drugs prescibed at discharge from hospital. Results: Prevalence of "Hidden" RF was 10.8 %. NKF cronic kidney disease stages 3.4 or 5 were present in 35.2 % of patients. Variables asociated with presence of "hidden" RF were age (expB = 1.035; IC95% 1.012 - 1.060; p = 0.004) and female sex (expB = 4.669; IC95% 2.461 - 8.856; p < 0.0001). Only in 1.8 % of cases GFR was calculated during hospitalitation period. A considerable number of patients with "hidden" RF received treatment with potentialy dangerous drugs taking into account his degree of renal failure. Conclusions: Our results support the introduction of GFR estimation by means of MDRD equation in laboratory reports

Keywords : Hidden renal failure; Drug prescription.

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