Abstract

LEYVA-HUERTA, E.R.; FLORES-FLORES, G.  and  GAITAN-CEPEDA, L.A.. Is AgNOR’s a useful tool as prognostic marker of oral cancer?. Av Odontoestomatol [online]. 2008, vol.24, n.3, pp.211-218. ISSN 2340-3152.

Background. It has been observes an increase in oral cancer cases, therefore it is necessary to have prognostic tools to identify oral cancer patients with high risk to progress to terminal stage. Aim. To establish if AgNOR’s are related to to histological grade of squamous cells carcinoma of oral cavity (SCCOC) and with the survival time of patients suffering SCCOC. Material and Methods. Nineteen archives cases of SCCOC, (Pathology Department, National Institute of cancer, México City), 3 cases of low grade, 7 cases of middle grade, and 9 cases of high grade of malignancy. From medical files it was obtained age at moment of diagnosis, gender, site of primary tumour and time of survival. From biological samples was obtained cut at 6 µm and stained with argental impregnation technique to Nucleolar Organization Regions of Ploton. From each case was determinate amount, size, and shape of AgNOR’s. The cases were grouped in regard to survival in: ≤11 months group (8 cases); and ≥12 months group (11 cases), and in regard to AgNOR’s average in: ≤8 AgNOR’s group (8 cases) and ≥9 AgNOR’s group (12 cases). The follows statistical tests were done: x², Pearson’s correlation, t student and multivariate logistic regression (p<0.05_IC95%). Results. AgNOR’s mean per nuclei = 9.05 (±2.01); AgNOR’s mean size = 3.5 nm. The ≥9 AgNOR’s group was related to high grade SCCOC (p<0.05) but not with survival time. It is suggest that quantity of AgNOR’s could be useful as an auxiliary tool to identify high grade SCCOC.

Keywords : Oral cancer; AgNOR’s; Prognostic markers.

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