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Avances en Odontoestomatología

versão On-line ISSN 2340-3152versão impressa ISSN 0213-1285


ASENSI ANTA, E et al. Factors associated with the malignization of oral lichen planus. Review of the literature. Av Odontoestomatol [online]. 2019, vol.35, n.3, pp.131-137.  Epub 18-Maio-2020. ISSN 2340-3152.


Lichen planus (LP) is a systemic autoimmune disease of unknown etiology and chronic course that can result in the development of oral squamous cell carcinoma (OECD).


To evaluate the evidence related to the malignization of the LPO as well as the clinical characteristics and the incidence of the lesions that can develop a COCE.

Material and methods:

The MEDLINE PubMed database of the last 5 years (2013-2018) was reviewed using the following keywords: “malignant transformation of oral lichen planus” and “squamous cell oral carcinoma”.


48 articles were obtained, after reading the summaries and applying our inclusion and exclusion criteria, we obtained a total of 19 articles, in addition to the 4 articles added by manual search. The review is based on the comparison of 9 cohort studies to analyze the incidence of progression from LPO to COCE.


We should consider the LPO as a potentially malignant disease (0.5-1%), being the female sex, the erosive type and the localization in the tongue as a risk factors for the transformation to COCE. Taking into account the risk of malignancy, it is essential to control the lesions in order to make an early diagnosis.

Palavras-chave : Malignant transformation of oral lichen planus; Squamous cell oral carcinoma; Oral lichen planus; Oral cancer.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )