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The European Journal of Psychiatry

Print version ISSN 0213-6163


CINAR RUGUL, Köse; YASEMIN, Görgülü; MEHMET BULENT, Sönmez  and  KILIC EVNUR, Kahyaci. Haematological and biochemical differences between mania and euthymia. Eur. J. Psychiat. [online]. 2016, vol.30, n.3, pp.163-171. ISSN 0213-6163.

Background and Objectives: The effects of transient hypothalamic dysfunction on the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid axes can be shown by haematological and biochemical parameter changes. We hypothesized that manic episodes will be associated with subclinical inflammation, haemodilution and altered thyroid functions compared to euthymic states. Methods: Patients admitted to the psychiatry clinic with manic episodes were identified. Those having comorbidities, except for thyroid dysfunctions, hypertension, hyperlipidemia, and type 2 diabetes mellitus, were excluded. Complete blood counts, total protein, albumin, and thyroid tests were recorded during the admissions (manic episodes) (Maletic, 2014 #24) and one year later (euthymic states) for the same patients. Results: All studied parameters had significant differences between mania and euthymia. During manic episodes, patients had higher peripheral inflammatory indices (neutrophil/lymphocyte ratio and platelet/lymphocyte ratio), haemodilution (lower haemoglobin, haematocrit, total protein, and albumin), higher thyroxine and lower thyroid-stimulating hormone levels compared to euthymic states. Conclusions: This study supports the hypothesis that compared to euthymic states; manic episodes are associated with low-grade inflammation, haemodilution and thyroid function abnormalities. Monitoring patients'; blood compositions could result in better prognostic evaluations and aid in determining additional systemic treatment options, as well as in generating causal hypothesis to be tested in future studies.

Keywords : Mania; Inflammation; Haemodilution.

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