Abstract

BARRIONUEVO ROSAS, Leslie; MASUET AUMATELL, Cristina  and  RAMON TORRELL, Josep M.. Effects of influenza vaccination on the percentage of CD4+ T lymphocytes in HIV 1/2 positive patients: a cohort study. Gac Sanit [online]. 2009, vol.23, n.4, pp.315-321. ISSN 0213-9111.

Objective: To determine the incidence of immunologic change in the percentage of CD4+ T lymphocytes in HIV 1/2 positive patients in the first quarter after influenza vaccination (P-CIR) and to compare the demographic and clinical characteristics associated with this change. Methods: We studied 105 patients with HIV/AIDS in a retrospective hospital cohort between 2001-2006. P-CIR was considered as a decrease of >3% in the prevaccination CD4+ percentage. Crude and adjusted OR (sex, age, antiretroviral therapy, clinical stability, prevaccination viremia and prevaccination total CD4) were evaluated by logistic regression (95%CI). Results: The incidence of P-CIR was 33.3%. P-CIR was persistent in 31.4% for 7 months after vaccination regardless of high prevaccination viremia. No association was found between demographic and clinical variables and P-CIR [crude OR: 0.90 (0.17-4.8); adjusted OR: 1.09 (0.17-6.8)]. Conclusions: The results showed that the immunological change after vaccination was not inconsiderable. However, this change was mainly transient.

Keywords : Influenza vaccines; HIV seropositivity; Acquired immunodeficiency syndrome; AIDS; CD4+ T lymphocytes; Viral load.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )