Abstract

ASENSIO-SANCHEZ, V.M.; GOMEZ-RAMIREZ, V.  and  MORALES-GOMEZ, I.. Erythropoietin concentrations in the vitreous body from patients with proliferative diabetic retinopathy. Arch Soc Esp Oftalmol [online]. 2008, vol.83, n.3, pp.169-172. ISSN 0365-6691.

Objective: To measure erythropoietin (Epo) levels in the vitreous body from patients with proliferative diabetic retinopathy (PDR). Patients and methods: Undiluted vitreous samples were obtained from 44 patients who had not undergone prior vitreous or intraocular surgery. Patients were divided into two groups: A (n= 24) patients with PDR and B (n= 20) patients with retinal detachment, preretinal macular membranes and macular holes. Epo was determined using radioimmunoassay. Results: Epo vitreous concentration in group A was 512 mU/mL (range 120-880) and in group B was 25.1 mU/mL (range 5.2-201) (p< 0.001). Conclusions: These results show that the concentration of Epo in the vitreous body was significantly higher in patients with PDR than in the control group.

Keywords : Diabetes; hypoxia; neuroprotection; angiogenesis; erythropoietin; proliferative diabetic retinopathy.

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