Abstract

CASADO SANCHEZ, César; CORDOBA CHICOTE, Vicenta; DOMINGUEZ FRANJO, María Purificación  and  VAQUERO PEREZ, María del Mar. Diagnostic limitations of preoperative immunohistochemical determinations in breast implant associated anaplastic large cell lymphoma (BIA-ALCL). Cir. plást. iberolatinoam. [online]. 2019, vol.45, n.3, pp.243-251.  Epub Dec 16, 2019. ISSN 1989-2055.  https://dx.doi.org/10.4321/s0376-78922019000300005.

We present a case of breast implant associated anaplastic large cell lymphoma (BIA-ALCL) that debuted as a left unilateral periprosthetic seroma of acellular features in its initial study. This aspect limited the immunohistochemical determination of CD30 markers and anaplastic lymphoma kinase (ALK) and its preoperative diagnosis.

Patient was operated performing implant removal and bilateral complete capsulectomy. The pathological study of the left periprosthetic capsule showed an anaplastic large cell lymphoma.

Since some cases of BIA-ALCL can occur without cellularity in the periprosthetic seroma, limiting the effectiveness of preoperative immunohistochemical determinations, in cases of high clinical suspicion an early surgical treatment could be considered in order to begin the oncological treatment without delay and providing a definitive diagnosis.

Keywords : Breast implant-associated large cell anaplastic lymphoma; Breast implants; Breast prosthesis; Delayed seroma.

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