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Cirugía Plástica Ibero-Latinoamericana

versión On-line ISSN 1989-2055versión impresa ISSN 0376-7892


PEREZ SANCHEZ, Yamilet  y  QUINTERO LARROVERE, Milagro. Serial treatment with platelet rich plasma in facial rejuvenation. Hystopathological and clinical changes. Cir. plást. iberolatinoam. [online]. 2020, vol.46, n.4, pp.421-440.  Epub 08-Feb-2021. ISSN 1989-2055.

Background and objective.

Facial aging remains a frequent cause for consultation in Plastic Surgery and one of the predominant concerns is how to stop or reverse this biological phenomenon without implying greater sacrifices. Platelet Rich Plasma (PRP) has been widely used in as an adjunct to many procedures, to improve facial contouring and as an anti-aging therapy, however, it is necessary to collect more histological and clinical evidence that supports the basis for designing of a biostimulator treatment in the facial region.

Our objective is to apply a serial treatment with PRP for facial rejuvenation and demonstrate its effectiveness through histopathological and clinical changes.


A prospective comparative self-control study was carried out between February and October 2017. The sample was represented by 14 patients with ritidosis, who were taken skin biopsy of the facial region to describe the previous histopathological characteristics, then 3 monthly sessions of PRP and a new skin biopsy after 6 months; then, rhytidectomy was performed with a third biopsy, and thus establish comparisons. Likewise, a photographic registry, clinical evaluation plus a personal assessment test were carried out to show the changes.


There was a statistically significant increase in the number of fibroblasts and collagen at 3 months of treatment with a mean of 95.71x mm2 and a mean of 75.7171x mm2 respectively; a significant increase in the thickness of the dermis was found with a average of 1.22 mm between 3 and 6 months and a significant increase in collagen with average values of 69.28% before treatment compared with 78.92% at 6 months.


Based on our results and application methodology, we consider that facial rejuvenation therapy with PRP is effective both from a histopathological and clinical point of view.

Palabras clave : Biostimulation; Platelet rich plasma; Facial rejuvenation.

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