SciELO - Scientific Electronic Library Online

vol.27 issue2Técnicas empleadas para el estudio de la interacción entre agentes antitumorales y el DNARadioterapia paliativa en niños: presentación de un caso clínico y recuerdo de sus indicaciones author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Oncología (Barcelona)

Print version ISSN 0378-4835


BUESO, P. et al. Resultados a largo plazo del tratamiento del estesioneuroblastoma: Experiencia en Aragón (1981-2003). Oncología (Barc.) [online]. 2004, vol.27, n.2, pp.44-48. ISSN 0378-4835.

PURPOSE: Esthesioneuroblastoma or olfactory neuroblastoma is an infrequent tumour with only one thousand cases reported in medical literature. Mean age at presentation is 50 years, and there is no sex predominance. It is a locally invasive tumour and late local relapses are frequent. Distant metastases have been reported (most frequent sites are lung and bone). We present our experience in management and treatment of this type of tumours. MATERIAL AND METHODS: Between 1981 and 2003, 8 cases of esthesioneuroblastoma were diagnosed in the University Hospital of Saragossa, Spain, an 882 bed-tertiary hospital, which is a reference for high-energy radiotherapy in Aragon. So this number of cases likely represents the total number of cases diagnosed in Aragon during this period. Sex was male in 5 and female in 3. Median age: 60 years (range 49-82). Most frequent symptoms at presentation were: nasal obstruction, nasal bleeding, anosmia, exophtalmos, palpebral edema and local swelling. Kadish stage at diagnosis: 3 patients stage B, 2 stage C and 3 stage D. Surgery, radiotherapy and chemotherapy were frequently combined. In two patients the treatment was surgery, alone in one patient and combined with radical radiotherapy in the other one. Three patients received chemotherapy, alone in two patients and combined with radiotherapy in the other one. Three patients were treated with radiotherapy alone. RESULTS: Two pacients remain alive and progression free at 87 and 108 months from the diagnosis and one more patient is on therapy. Four patients died with prognosis at 6, 8, 38 and 63 months from diagnosis. One pacient died of a second tumour 36 months from diagnosis. CONCLUSION: Local control is essential for long term survival in esthesioneuroblastoma.

Keywords : Esthesioneuroblastoma; Neuroblastoma; Surgery; Radiotherapy; Chemotherapy.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License