Abstract

VALERDIZ CASASOLA, S.; MENENDEZ COLUNGA, M. J.; ALLER MILLAN, O.  and  MARTINEZ RODRIGUEZ, J. M.. Pronostic value of clinicopathologic factors Ki67, cyclin D1, cyclin D3 and CDK4 in gastric carcinoma. Oncología (Barc.) [online]. 2004, vol.27, n.9, pp.31-37. ISSN 0378-4835.

PURPOSE: To estimate the prognostic value of cyclin D1, Ki67, cyclin D3, cdk4 and classical clinicopathologic features of gastric carcinoma alone and in combination. MATERIAL AND METHODS: We investigated the expression of cyclin D1, cyclin D3, cdk4 and Ki67 in gastric carcinoma. They were analyzed by immunohistochemical stain in formalin-fixed, paraffin-embedded tissue sections from 74 patients with gastric carcinoma, using automated methods. Immunostains, Ki67 proliferation index, histologic grade and histological type (Lauren classification) were compared with the length of survival. RESULTS: Positive immunostaining was shown in 97% of the cases for Ki67, in 29% for cyclin D1, in 23% for cyclin D3, and in 35% for cdk4. On multivariate analysis only Ki67 (PI) (p<0.01) and pathologic grade (p<0.03) correlated with the length of survival. Expression of cyclin D3 was related with cdk4 (p<0.001) and Ki67 (PI) (p<0.02), and expression of cyclyn D1 was related with histologic grade (p<0.03). CONCLUSIONS: Our results suggest that higher proliferation index of Ki67 and histological grade could be useful as markers of poorer prognosis. Over-expression of cyclin D1 could be an important role in cell proliferation. The relations between cyclin D3, cdk4 and Ki67 might be explained by the role of cyclin D3 and cdk4 in the cell cycle and the expression of Ki67 along the cellular cycle.

Keywords : Gastric carcinoma; Ki67; Cdk4; Cyclin.

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