Abstract

HARGUINDEY, S.. Apoptosis y antiapoptosis en cáncer, Alzheimer y procesos neurodegenerativos: ¿una dialéctica de contrarios? Nuevo abanico de posibilidades terapéuticas y peligros potenciales. Oncología (Barc.) [online]. 2004, vol.27, n.10, pp.27-37. ISSN 0378-4835.

The intricated pathways of intracellular signaling and the deregulation of cell apoptosis, either spontaneous or induced, are becoming the main molecular and therapeutic targets ranging from cancer to neurodegenerative diseases. Modern trends in research and treatment show that the failure to induce selective cancer cell and tamor apoptosis (proapoptosis), and, in the opposite direction, the failure to prevent the spontaneous apoptosis of neurodegenerative diseases, like Alzheimer's disease, can be interpreted as problems representing two branches, or areas, of medicine growing in an opposite direction. The approach here advanced represents an attempt to stimulate an integral vision of both branches or areas of research, oncology and neurology, hoping to improve the understanding of the intimate nature of the basic and clinical abnormalities under investigation. A stop by step differentiation of the therapeutic possibilities that are being opened nowadays is considered, as well as some preliminary and potential dangers raised by the very same treatment efforts.

Keywords : Apoptosis; Antiapoptosis; pH; Cancer; Alzheimerts disease; Neurodegenerative diseases; p53; Growth factors.

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