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Oncología (Barcelona)

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RUBIALES, A. S. et al. Reacción de llamarada en el cáncer de mama avanzado. Oncología (Barc.) [online]. 2005, vol.28, n.1, pp.51-55. ISSN 0378-4835.

PURPOSE: Flare reaction presents initially as a treatment-induced apparent rise of tumor activity. It can manifest as an increase of metabolism in the tumor lesions, most frequently bone metastases. The presentation involving other manifestations as pain or metabolic disorders is infrequent. MATERIAL AND METHODS: We present two patients with advanced breast cancer that developed a flare reaction induced by hormone therapy (tamoxifen) in one case, and by chemotherapy in the other. RESULTS: Both patients suffered initially an increase in pain intensity with a parallel elevation of tumor markers. Later was evidenced a clear response. We underline the manuscript of the second patient where she describes her own feelings and symptoms during the flare. CONCLUSIONS: Flare reaction can manifest as an apparent transient worsening of the disease, followed up by an evident tumor response.

Keywords : Flare reaction; Advanced breast cancer.

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