Abstract

VASSAUX, G. et al. Caspase-1 as a radio and chemosensitizer regardless of JNK and p38 pathways. Oncología (Barc.) [online]. 2005, vol.28, n.8, pp.42-54. ISSN 0378-4835.

The cytotoxic effect of anticancer drugs has been shown to involve induction of apoptosis. This observation raises the possibility that factors affecting caspase activation might be important determinants as anticancer drug sensitivity. Ectopic expression of caspase-1 has been shown to trigger apoptosis. Here, we examine the effect of caspase-1 over-expression on the response to chemotherapy and radiotherapy. Caspase-1 expression mediated by an adenoviral vector was able to kill directly cells and to sensitize the remaining cells to cisplatin or g-radiation in vitro. In HeLa cells stably transfected with caspase-1, sensitisation to cisplatin was due to an amplification of the cisplatin-induced mitochondrial apoptotic pathway activation but this effect is independent of p53, JNK or p38 status.

Keywords : Caspase-1; Chemo and radiosensitization; Kinases and p53.

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