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Oncología (Barcelona)

versão impressa ISSN 0378-4835


MORENO-VEGA, A. L. et al. Concurrence of neurologic paraneoplastic syndromes in a woman with brain metastatic breast cancer: review of the literature. Oncología (Barc.) [online]. 2006, vol.29, n.2, pp.34-38. ISSN 0378-4835.

Neurological paraneoplastic syndromes are complex entities of difficult diagnosis. They can locate in any part of the nervous system producing important neurological dysfunctions. The discovery of new specific anti-neuronal antibodies and their relation with the associated immunological alterations help to make an early diagnosis. Association with breast cancer is not frequent. We present the case of a 62-year old patient with left breast carcinoma that had been treated by mastectomy and adjuvant chemotherapy one year before. She relapsed with cerebellum metastases and was treated by surgery and radiotherapy. The picture was complicated with a Lambert-Eaton-like myasthenic syndrome, neuroplastic sensory neuronopathy, limbic encephalitis and irreversible coma. The application of new diagnostic criteria, the molecular discoveries and the performance of therapeutic clinical trials could better the life expectancy of these patients.

Palavras-chave : Onconeuronal antibodies; Breast cancer; Limbic encephalitis; Chemotherapy; Lambert-Eaton syndrome; Neurological paraneoplastic syndrome.

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