SciELO - Scientific Electronic Library Online

vol.29 issue4Clinical impact of PET-18 FDG in selecting the therapy of oncologic patientsKidney collition tumor: an unusual case of renal cell carcinoma and renal leiomyosarcoma author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Oncología (Barcelona)

Print version ISSN 0378-4835


ESTEBAN, E. et al. Adjuvant anti-hormonal treatment of postmenopausal women with breast cancer. Oncología (Barc.) [online]. 2006, vol.29, n.4, pp.26-35. ISSN 0378-4835.

Over the recent decades, tamoxifen has been considered the standard adjuvant treatment of postmenopausal women with hormone-receptor positive breast cancer based on its capacity to reduce the annual breast cancer death. More recently, several major randomized controlled trials carried out with three different new aromatase inhibitors used either from the time of primary surgery or after 2-3 or 5 years of adjuvant tamoxifen therapy have shown a significant improvement in disease-free survival with respect to tamoxifen therapy. The described treatment-related side effects suggest different profiles of toxicity. Musculoskeletal disorders and cardiovascular events are the most serious side effects associated with the use of aromatase inhibitors, as well as the thromboembolic events and endometrial abnormalities are associated with tamoxifen therapy. An optimal treatment strategy for aromatase inhibitors administration, interventions to prevent or alleviate treatment-related side effects and identification of women at higher risk having more benefit with aromatase inhibitors need to be addressed.

Keywords : Breast cancer; Adjuvant therapy; Aromatase inhibitors; Tamoxifen.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License