Abstract

MEDIALDEA CRUZ, Jesús  and  MEDINA FONT, Jua. Influence of the body mass index and other metabolic factors on the C-reactive protein: Considerations as a possible biomarker of comorbidity and psychiatric aspects. Med. segur. trab. [online]. 2012, vol.58, n.228, pp.261-268. ISSN 1989-7790.  https://dx.doi.org/10.4321/S0465-546X2012000300010.

Objectives: Overweight and obesity has been studied under a lot point of views because of the high incidence, heterogeneity and medical complications. In this paper, the total number of subjects (n= 123) were selected from a Spanish population (airline pilots, air traffic controllers and other crew members) in order to investigate: 1) Association between Body Mass Index (BMI) and C-reactive protein (CRP) levels; 2) Incidence of Metabolic Syndrome (MS); 3) Relationship between MS and CRP levels; 4) Relationship between CRP levels and number of diagnostic criteria of MS; 5) Finally, some considerations under the psychiatric point of view are made based on the results and current literature. Methods: The sample consists of 123 subjects. Anthropometric values, blood pressure, CRP concentration and other medical and metabolic parameters (triglycerides, HDL-cholesterol, glucose, cholesterol), were calculated according to the standard procedures. Results: The incidence of MS was 36.5%, they all had a high level of CRP. There were relations between the number of diagnostic criteria of MS and CRP serum level. Obesity and overweight have been found to exhibit increased CRP serum level too. Conclusions: CRP is an inflammatory parameter that can helps us to suspect co-morbidity of MS among overweight and obesity population. Increased levels of CRP suggests that there may be a common inflammatory mechanism that can lead to developing cardiovascular, metabolic and psychiatric diseases. Treatment implications are considered.

Keywords : Obesity; overweight; metabolic syndrome; C-reactive protein; inflammation.

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