Abstract

ROJAS-GARCIA, Yosimar  and  PENALVER-PAOLINI, Andreína. Occupational exposure to wood dust and Paranasal Sinus Cancer. Med. segur. trab. [online]. 2015, vol.61, n.238, pp.112-124. ISSN 1989-7790.  https://dx.doi.org/10.4321/S0465-546X2015000100010.

Introduction: Nasal Cavity and Paranasal Sinus Cancer are relatively uncommon. They account for just 0.2%-0.8% of all cancers and for 3% of the upper respiratory tract tumours. Occupational exposure to certain substances, such as the exposure to wood dust, may account for 40% of cases. Objective: Review the recent scientific literature dealing with occupational exposure to wood dust and its relation with the development of paranasal sinus cancer. Material and Methods: Bibliographic search of articles published between 2009-2014 in the main biomedical databases (Medline, Lilacs, Ibecs, Scielo, OSH-Update, and Cochrane library) and selected articles according with inclusion-and-exclusion criteria. Results: 7 articles obtained 2 cases-control articles, 3 longitudinal retrospective articles, 1 case series studies and 1 transversal study. Conclusions: There is a relevant statistical association between wood dust labour exposure and paranasal sinus cancer. Such susceptibility may increase with heavier exposure or longer exposure time. TP53 and K-ras gene mutation, p53 inmunopositivity and polymorphism enzymes of CYP1A metabolism are genetic alterations involved with the exposure which are as well part of the pathology development.

Keywords : Occupational exposure; wood dust; Paranasal Sinus Neoplasms.

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