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Medicina y Seguridad del Trabajo

On-line version ISSN 1989-7790Print version ISSN 0465-546X


IKNUROV MOLLOV, Asan; MARTINEZ PONCE, Diana Cecily; SERRANO PUEBLA, José Mª  and  ELIAS SALCEDO, Sergi. Pesticides Exposure at Workplace, Gene Expression and Parkinson’s disease. Med. segur. trab. [online]. 2017, vol.63, n.246, pp.68-84. ISSN 1989-7790.


Several occupational exposures may increase the risk of developing Parkinson’s disease. Exposure to pesticides is a known risk factor but is never enough to cause PD. Other factors, such as susceptibility of different genetic variants are believed to be necessary.


To identify the scientific evidence between pesticides exposure and genetic predisposition for a PD outbreak at workplace. To specify genes and their variables that may change the risk of developing the disease. To identify intrinsic and extrinsic factors that influence Parkinson’s disease risk. To know the professional activities that may increase the risk.


Bibliographic search for systematic review in scientific articles published over the last 10 years in the following databases: MEDLINE (through Pubmed), LILACS, IBECS, SCIELO Network, COCHRANE LIBRARY, using terms (MeSH terms). Level of evidence was based on the SIGN criteria.


We retrieved 148 articles. 9 articles remained after applying the inclusion and exclusion criteria. The articles selected are case-control, two of them are case-control nested in a cohort. Results of all studies were statistically significant.


An association between the genetic variable studied, pesticides exposure and the development of PD or a reduction of PD for all onset ages with a high level of evidence were found in all the articles reviewed.

Keywords : systematic review; genetics; pesticides; Parkinson’s disease; occupational exposure.

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