Abstract

RIVERO FERNANDEZ, M. et al. Recurrent acute liver toxicity from intravenous methyprednisolone. Rev. esp. enferm. dig. [online]. 2008, vol.100, n.11, pp.720-723. ISSN 1130-0108.

Adverse drug reactions (hepatotoxicity) are a frequent cause of acute liver injury with a wide clinical and histological spectrum. An early recognition of drug-related liver disease has been considered essential in clinical practice due to potential risks. In most cases exposure discontinuation improves the clinical picture. Steroids are used in a variety of clinical settings. However, intravenous steroids have rarely been associated with hepatotoxicity. We report the case of a middle-aged woman with multiple sclerosis who received a bolus of methylprednisolone on three occasions for the management of relapsing disease, with the development of repeated episodes of elevated liver enzymes after corticoid administration. In the third episode a liver biopsy was performed, which showed acute hepatitis with bridging necrosis; such histological picture has not been described before in patients treated with intravenous steroids.

Keywords : Methylprednisolone; Hepatotoxicity; Multiple sclerosis.

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