Abstract

URIBARRENA-AMEZAGA, R. et al. Prognostic value of lymph node micrometastases in patients with colorectal cancer in Dukes stages A and B (T1-T4, N0, M0). Rev. esp. enferm. dig. [online]. 2010, vol.102, n.3, pp.176-186. ISSN 1130-0108.

Background: 30% of patients with colorectal cancer (CRC) in Dukes stages A and B (T1-T4, N0, M0) present tumor recurrence and die after 5 years follow up. This unexpectedly poor evolution might be attributable to the presence of lymph node micrometastasis undetected in routine examination with haematoxilin-eosine (H&E). Objective: to assess the presence of undetected micrometastasis. Patients and methods: we conducted a retrospective study of the locoregional lymph nodes in 85 patients operated for CRC in Dukes stages A and B (T1-T4, N0, M0), using immunohistochemistry with anticytokeratin antibodies AE1/AE3. In this descriptive, inferential bivariant and survival study, we analyzed different risk factors, including local infiltration T1/T4, Dukes A/B, number of dissected lymph nodes, vascular invasion, micrometastasis, tumor recurrence and death in the context of the presence or absence of micrometastases. Results: Dukes stage and neoplastic angioinvasion are influential in patient prognosis; however, lymph node micrometastases were not associated with a poorer outcome of CRC. Conclusions: locorregional lymph node micrometastases detected with anticytokeratine antibodies AE1/AE3 in Dukes A and B CRC patients are not associated with reduced survival.

Keywords : Colorectal adenocarcinoma; Prognosis; Micrometastases.

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