Abstract

LOPEZ-TOMASSETTI-FERNANDEZ, Eudaldo M.; FAVRE-RIZZO, Julián; DELGADO-PLASENCIA, Luciano  and  HERNANDEZ-HERNANDEZ, Juan Ramón. Hipercalcemia asociada a carcinoma adenoescamoso de páncreas: razones para iniciar tratamiento paliativo. Rev. esp. enferm. dig. [online]. 2013, vol.105, n.7, pp.425-428. ISSN 1130-0108.  https://dx.doi.org/10.4321/S1130-01082013000700009.

Background: hypercalcemia in patients with diagnosed carcinoma has predominantly a humoral basis mediated by parathyroid hormone-related protein (PTH-rP). Among the reported cases, hypercalcemia associated with the majority of abdominal malignancies indicates an advanced stage of disease. Case report: we present a case of a 78-year-old patient with an adenosquamous pancreatic carcinoma associated with humoral hypercalcemia mediated by PTH-rP. Conclusion: in this case, demonstration of unexpectantly rapid increase in calcium serum correlated with aggressive tumor growth led us to raise the hypothesis that PTH-rP could be a mediator of invasion and dissemination secreted by some tumors, and probably indicates the appropriate time to initiate palliative treatment.

Keywords : Adenosquamous carcinoma; Pancreatic malignancy; Humoral hypercalcemia.

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