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Revista Española de Enfermedades Digestivas

Print version ISSN 1130-0108


FERNANDES, Samuel Raimundo et al. Severe ischemic colitis following olanzapine use: a Case Report. Rev. esp. enferm. dig. [online]. 2016, vol.108, n.9, pp.595-598. ISSN 1130-0108.

Ischemic colitis is the most common subtype of intestinal ischemia usually resulting from vasospasm, vessel occlusion or mesenteric hypoperfusion. Neuroleptics have seldom been linked to ischemic colitis by blocking peripheral anticholinergic and antiserotonergic receptors inducing severe gastrointestinal paresis. We report a young patient with severe ischemic colitis requiring surgery due to necrosis of the bowel. After exclusion of other potential causes, olanzapine was admitted as the cause of ischemia. Clinicians should be aware of how to recognize and treat the potentially life-threatening effects of neuroleptics.

Keywords : Neuroleptics; Olanzapine; Ischemic colitis.

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